Bishop Gray retired in 19 1 0. On Ascension Day in that year, he presented to the Cathedral as a thank offering a processional cross which is still in use. The carved oak pulpit in the Cathedral is a memorial to Bishop Gray.

The Rt. Rev. Cameron Mann, Bishop of North Dakota, succeeded Bishop Gray. A series of Deans offered leadership that steadily advanced the growth of the parish and its spiritual influence throughout the period of World War I and the 1920's. At the General Convention of 1922, the Missionary Jurisdiction of South Florida was admitted as a Diocese and the first Diocesan Convention was held in the Cathedral in January, 1923.

In October, 1922, the old Cathedral building was moved to the south side of the tract of land to make room for a glorious new Cathedral. It was designed by the famous architects of the Washington Cathedral, the firm of Frohman, Robb, and Little of Boston. The cornerstone was laid by Bishop Mann on April 13,1925.

Because of the depression, which came to Florida in 1926, the building was only partially constructed. A "temporary" wall sealed the altar end. The first services were conducted in the new Cathedral on Easter Even, April 3,1926, by Bishop Mann, when a large confirmation class was presented to him.

The ensuing period presented severe economic hardships. Members of the Cathedral parish made significant sacrifices to keep and maintain the properties they had worked so hard to obtain.

John Durham Wing was elected and consecrated as Bishop Coadjutor on September 25,1925. He succeeded Bishop Mann in 1932, and his installation service was held in the Cathedral on May 12.

The Rev. Melville F. Johnson, student pastor at the University of Florida, became the sixth Dean on January 1, 1 931 and served for twenty-two years. He led the construction of the L-shaped educational unit, which stands behind the present Chapter House. It was a memorial to members of the Cathedral who died in World War II.

The Rev. Osborne R. Littleford became the Cathedral's seventh Dean in 1952. Under his leadership, the present Chapter House was erected and the Cathedral parish grew steadily. At this time several of the suburban churches were established, and many of the Cathedral families transferred to them to help form a foundation for their growth.

In 1959, the Rev. Francis Campbell Gray became the eighth Dean and guided the destiny of the Cathedral family for twelve years. During his tenure, communicant strength reached a new high.

The Rt. Rev. Henry Irving Louttit, who had served as Suffragan from 1945 to 1948 and as Coadjutor from 1948 to 1950, directed the Diocese of South Florida during its greatest period of growth and expansion. New parishes proliferated. Diocesan communicant strength tripled. As he approached retirement, machinery was set up through Convention to study the possibility of dividing the Diocese of South Florida. This was accomplished in 1970 when the old Diocese of South Florida was divided into three dioceses. St. Luke's continued as the Cathedral Church for the Diocese of Central Florida. Bishop Louttit served very briefly as its first Bishop, succeeded by the Rt. Rev. William H. Folwell who retired in 1990. The Rt. Rev. John W. Howe followed Bishop Folwell and is the present bishop of the Diocese of Central Florida.

In January, 1971, the Rev. Charles T. Gaskell became the ninth Dean of the Cathedral, serving until his consecration in June, 1973, as Bishop Coadjutor of Milwaukee. Under Dean Gaskell's leadership the renovation of the Cathedral nave, with the erection of the choir gallery over the narthex and installation of the 88-rank pipe organ was achieved.

In September, 1973, the Rev. O'Kelley Whitaker, Rector of Emmanuel Church, Orlando, became the tenth Dean. With Bishop Folwell's encouragement, under Dean Whitaker's leadership, the Cathedral grew as a strong downtown parish, became a center for Diocesan functions and an example of excellence in worship, liturgical arts and music.

Dean Whitaker resigned after his election as Bishop Coadjutor of the Diocese of Central New York in November, 1980. The Rev. George H. Back (current Dean of the Cathedral in Oklahoma City) served as Interim Dean for one year.

The Rev. Harry B. Sherman, rector of St. Paul's Church, Patchogue, Long Island, and Dean of Suffolk County in the Diocese of Long Island, accepted the call to become the eleventh Dean of the Cathedral, beginning his ministry at the Cathedral on September 1, 1981.

Through 1986 and 1987, the temporary wall which was constructed in 1926, was removed and the Cathedral building was finally completed much as it had been originally planned, The completed Cathedral includes an apse, ambulatory, priests and working sacristies, a bell tower and the St. Mary Chapel.

Under the leadership of The Very Rev. Dr. G. Richard Lobs III, the twelfth dean, from 1993 to 2006, the Cathedral experienced substantial spiritual and numerical growth. That growth and vitality continue with the Cathedral's thirteenth dean, The Very Rev. Anthony P. Clark, who was installed in December 2006. The congregation looks forward to continuing excellence in worship and growth in the knowledge and love of Jesus Christ under Dean Clark's leadership.